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Procaine hydrochloride

Procaine hydrochloride Supplier
Procaine hydrochloride Powder
Common Name Procaine hydrochloride
CAS Number 51-05-8
Molecular Weight 272.771
Density N/A
Boiling Point 195-196°C 17mm
Molecular Formula C13H21ClN2O2
Melting Point 155-156 °C(lit.)
Flash Point 195-196°C/17mm
Symbol GHS06
Purity 99%
Exact Mass 272.129150
PSA 55.56000
LogP 3.15060
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility soluble

Use of Procaine hydrochloride
Procaine Hydrochloride is a local anesthetic drug of the amino ester group.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale [3].

Uses Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.
Application Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length. It has also been used as an inducer in M9 media for induction assay. It is a sodium channel blocker and DNA methylation inhibitor.

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